tag:blogger.com,1999:blog-90126892399557724192024-03-14T07:14:01.672+09:00Issei Komuro group - image manipulation -Issei Komuro:
Visiting Professor and Chairman‚ Graduate School of Medicine‚ Chiba University, Chiba, Japan;
Professor‚ Graduate School of Medicine‚ Osaka University, Osaka, Japan;
Professor‚ Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.comBlogger13125tag:blogger.com,1999:blog-9012689239955772419.post-53659110225184722962013-05-05T16:41:00.000+09:002014-04-22T22:42:10.883+09:00Summary of inappropriate image manipulation by Issei Komuro's group.<div>
<a href="http://isseikomuro.blogspot.com/2013/05/cell-2012-jun-814961298-313.html">Cell. 2012 Jun 8;149(6):1298-313.</a></div>
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Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.<br />
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<a href="http://isseikomuro.blogspot.com/2013/05/nature.html">Nature. 2012 May 10;485(7397):251-5.</a></div>
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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.</div>
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<a href="http://isseikomuro.blogspot.com/2013/05/j-atheroscler-thromb-2012193263-75.html">J Atheroscler Thromb. 2012;19(3):263-75.</a></div>
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Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases.</div>
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<a href="http://isseikomuro.blogspot.com/2013/05/nat-med-2009-sep1591082-7.html">Nat Med. 2009 Sep;15(9):1082-7.</a></div>
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A crucial role for adipose tissue p53 in the regulation of insulin resistance.</div>
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<a href="http://isseikomuro.blogspot.com/2013/05/nature-2008-jul-174547202345-9.html">Nature. 2008 Jul 17;454(7202):345-9.</a><br />
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.<br />
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<a href="http://isseikomuro.blogspot.com/2013/05/j-biol-chem.html">J Biol Chem. 2004 Mar 19;279(12):11384-91.</a><br />
Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes.<br />
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<a href="http://isseikomuro.blogspot.com/2013/05/biochem-biophys-res-commun-2004-sep.html">Biochem Biophys Res Commun. 2004 Sep 10;322(1):310-9.</a><br />
Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1.<br />
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<a href="http://isseikomuro.blogspot.com/2013/05/nat-cell-biol-2004-jun66499-506.html">Nat Cell Biol. 2004 Jun;6(6):499-506.</a><br />
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.<br />
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<a href="http://isseikomuro.blogspot.com/2013/05/circulation-2003-dec-16108243024-30.html">Circulation. 2003 Dec 16;108(24):3024-30.</a><br />
Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury.<br />
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<a href="http://isseikomuro.blogspot.com/2013/05/circulation-2002-sep-10106111397-402.html">Circulation. 2002 Sep 10;106(11):1397-402.</a><br />
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C.<br />
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<a href="http://isseikomuro.blogspot.com/2013/05/circulation-2002-mar-12105101240-6.html">Circulation. 2002 Mar 12;105(10):1240-6.</a><br />
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.<br />
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<a href="http://isseikomuro.blogspot.com/2013/05/j-biol-chem-1999-mar-19274128231-9.html">J Biol Chem. 1999 Mar 19;274(12):8231-9.</a><br />
Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.<br />
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<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><b>Coverage of the media on this matter</b></span><br />
Forbes: <a href="http://www.forbes.com/sites/larryhusten/2013/05/10/suspicions-raised-about-another-japanese-cardiovascular-researcher/">Suspicions Raised About Another Japanese Cardiovascular Researcher</a> (<a href="http://megalodon.jp/2013-0512-2343-28/www.forbes.com/sites/larryhusten/2013/05/10/suspicions-raised-about-another-japanese-cardiovascular-researcher/">copy</a>)<br />
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com4tag:blogger.com,1999:blog-9012689239955772419.post-63070059568308272342013-05-04T23:53:00.000+09:002013-07-07T02:24:55.977+09:00Circulation. 2002 Sep 10;106(11):1397-402.<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<span role="menubar">Circulation.</span> 2002 Sep 10;106(11):1397-402.</div>
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Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.666666984558105px;">Sato M, Toyozaki T, Odaka K, Uehara T, Arano Y, Hasegawa H, Yoshida K, Imanaka-Yoshida K, Yoshida T, Hiroe M, Tadokoro H, Irie T, Tanada S,Komuro I.</span></span></div>
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Source</h3>
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Department of Cardiovascular Science and Medicine, Graduate School of Medicine, Chiba University, Chiba-shi, Chiba, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/12221059">http://www.ncbi.nlm.nih.gov/pubmed/12221059</a></div>
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<a href="http://circ.ahajournals.org/content/106/11/1397.long">http://circ.ahajournals.org/content/106/11/1397.long</a></div>
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<a href="http://circ.ahajournals.org/content/106/11/1397.full.pdf+html">http://circ.ahajournals.org/content/106/11/1397.full.pdf+html</a></div>
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<span style="color: red; font-family: arial, helvetica, clean, sans-serif;"><span style="line-height: 14.770833015441895px;"><b>In figure 3, the image of 3-c is the same image of 165 degrees-clockwise rotated and size-reduced version of 2-c.</b></span></span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEicwZNEih8wKtVpRmfw4MRwZSrvY4QIH55WHvSyeFA7Y30t-Q5yZsFIbpCsmjJvGr8D6ihISg47JmHvwd7uVMFsnQBVbki8WWHK8kGEAtBYSbRMQfNpL8m3J1aNzYDw08x7PFgmf6rixh3q/s1600/Figure3.jpg" imageanchor="1" style="font-size: medium; line-height: 17.45833396911621px; margin-left: 1em; margin-right: 1em; text-align: center;"><img border="0" height="326" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEicwZNEih8wKtVpRmfw4MRwZSrvY4QIH55WHvSyeFA7Y30t-Q5yZsFIbpCsmjJvGr8D6ihISg47JmHvwd7uVMFsnQBVbki8WWHK8kGEAtBYSbRMQfNpL8m3J1aNzYDw08x7PFgmf6rixh3q/s400/Figure3.jpg" width="400" /></a></div>
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<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">国立大学法人千葉大学学術国際部研究推進課長様 </span><br />
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<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">千葉大学大学院医学研究院循環病態医科学グループの研究活動の不正行為の疑惑に関して申立てましたXXXXXXX と申します(平成25年5月30日付けで受理)。 </span><br />
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<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">前回送付した申立書において、千葉大学に所属していた小室一成氏らのグループから発表された14報の論文について研究不正の疑義を申立てていましたが、さらに同グループから発表された下記の別の論文1報に関して実験画像の流用(捏造・改ざん)の疑いが見つかりましたのでお知らせいたします。この論文の疑義に関しても調査していただけないでしょうか。論文名および不正疑惑の具体的内容は下記の通りです。このメールに添付した不正疑義の解説図(Figure3.jpg)もご参照ください。 </span><br />
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<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">論文名: </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">Circulation. 2002 Sep 10;106(11):1397-402. </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">Sato M, Toyozaki T, Odaka K, Uehara T, Arano Y, Hasegawa H, Yoshida K, Imanaka-Yoshida K, Yoshida T, Hiroe M, Tadokoro H, Irie T, Tanada S,Komuro I. </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">Source </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">Department of Cardiovascular Science and Medicine, Graduate School of Medicine, Chiba University, Chiba-shi, Chiba, Japan. </span><br />
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<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">不正疑惑の具体的内容: </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">Figure 3において、2-cの画像を時計回りに165度回転させ、サイズを90%に縮小させたものに、3-cの画像が類似しています。 </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">2-cと3-cの画像は互いに異なる個体から由来するものであるはずですが、互いに類似しているのは極めて不自然です。 </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">これが、不適切な画像流用だとすると、元の画像を回転させたり、サイズを変更したりするなどの操作を加えていることから、意図的に研究不正を働いた可能性が推測されます。2-cの画像は2-aと2-bに輪郭がほとんど一致していることから、2-cの画像がオリジナル画像と推測され、その場合、3-cが流用画像となりますが、つじつまを合わせるために、3-cの輪郭も3-aや3-bの画像の輪郭に近くなるように、画像の回転角度やサイズが調整され流用されています。よって、意図的な不正である可能性が極めて高いと考えれます。 </span><br />
<span style="background-color: white; color: blue; font-family: 'MS PGothic'; line-height: 18px;">不正の有無について調査をよろしくお願いいたします。 </span><br />
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<a href="http://blog.m3.com/flyingmedicords" style="color: #666666;">ブルースin東京/Blues in Tokyo・Yumemi</a> より</h1>
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<a href="http://blog.m3.com/flyingmedicords/20130623/1" style="color: #321800; text-decoration: none;">「あ・・。開いた口が。。。」</a></h2>
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<a href="http://blog.m3.com/users/270630/profile" style="color: #b35400;">夢見る掃除人</a> / 2013.06.23 16:36 / 推薦数 : 8</div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 24pt;"><span style="color: #3300cc;">「あ・・。</span><span style="color: #ff0099;">開</span><span style="color: #0099cc;">い</span><span style="color: #993300;">た</span><span style="color: #663399;">口</span><span style="color: red;">が</span><span style="color: #cc0099;">。</span><span style="color: #ff9900;">。</span><span style="color: #cc0033;">。</span><span style="color: #000099;">」</span></span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;">―</span><span style="color: black; font-family: 'Calligraph421 BT'; font-size: 18pt;"> Wow! It sure is jaw-dropping. </span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;">―</span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> 先に解析した画像トリックについて、もうちょっと突っ込んでみましょう。</span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> ひとつの画像が別の画像に捏り変えることができるということは、その逆も成り立ちます。</span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> すなわち、</span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #009900;">3-c</span></span><span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">→</span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #006699;">2-c</span></span><span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">なら、<span style="font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #006699;">2-c</span></span></span><span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">→<span style="font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #009900;">3-c</span></span></span><span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">も成り立つということです。</span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><img alt="" border="0" height="375" src="http://blog.m3.com/flyingmedicords/files/Circulation+2002+%28106%29%E3%82%A2%E3%83%B3%E3%82%B3%E3%82%A6%E3%81%9D%E3%81%AE%EF%BC%91%E6%89%8B%E7%9B%B4%E3%81%972Komuro.jpg" style="border: none; height: 375px; width: 500px;" width="500" /> </span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> 二枚しかなかったら、どっちがどっちかわかります?わからないでしょ。</span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> 「こんなことして何になる」と言われるかもしれませんが、捏られた画像の特徴をもっとよく観察してみましょう。</span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> 「アングリ開いたアンコウの口」に見えてきませんか</span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;">?</span><span style="color: #ff66ff;"><span style="font-family: Century; font-size: small;"><a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="See? でしょん?"><img alt="実写、動物、かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/04ctj_717328/%E5%AE%9F%E5%86%99%E3%80%81%E5%8B%95%E7%89%A9%E3%80%81%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.GIF" style="border: none;" /></a></span></span><span style="color: #ff66ff;"><span style="font-size: small;"><span style="font-family: Century;"></span></span></span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><img alt="" border="0" height="375" src="http://blog.m3.com/flyingmedicords/files/Circulation+2002+%28106%29%E3%82%A2%E3%83%B3%E3%82%B3%E3%82%A6%E3%81%9D%E3%81%AE2Komuro.jpg" style="border: none; height: 375px; width: 500px;" width="500" /> </span></div>
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<span style="font-family: 'MS Pゴシック'; font-size: 9.5pt;"><a href="http://circ.ahajournals.org/content/106/11/1397.full.pdf+html" style="color: #b35400;" target="_blank" title="Circulation 2002 (106) Chiba Paper"><img alt="" border="0" height="375" src="http://blog.m3.com/flyingmedicords/files/Circulation+2002+%28106%29%E3%82%A2%E3%83%B3%E3%82%B3%E3%82%A6%E3%81%9D%E3%81%AE3%E3%81%A8%E3%82%8A%E3%81%BF%E3%82%93%E3%81%90Komurojpeg.jpg" style="border: none; height: 375px; width: 500px;" width="500" /></a></span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><span style="font-size: 14pt;"> もともと口がないはずの</span><span style="font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;">3-a</span> </span><span style="font-size: 14pt;">と</span><span style="font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;">3-b</span></span><span style="font-size: 14pt;">の左端に、それらしく削って捏っているのがお <a href="http://emoji7.jp/051ga_719874/%E3%82%AD%E3%83%A3%E3%83%A9%E3%81%AA%E3%81%A9/" style="color: #b35400;"><img alt="キャラなど のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/051ga_719874/%E3%82%AD%E3%83%A3%E3%83%A9%E3%81%AA%E3%81%A9_m.gif" style="border: none;" /></a> かりでしょうか</span><span style="font-family: 'Times New Roman', serif; font-size: 14pt;">?</span></span></div>
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<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">【補足的考察】</span></span></span></span></div>
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<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;"> </span><span style="color: red;">原図<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #006699;">2-c</span></span></span></span><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">から</span></span><span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: 14pt;"><span style="color: #009900;">3-c</span></span></span><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">を捏り、その後、口を合わせるために、</span></span><span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: #ff0099;">3-b</span></span><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">と<span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: #ff0099;">3-a</span></span></span></span></span><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">の左端を巧妙に削った</span><span style="color: red;">。。。そなの?</span></span></span></span></div>
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<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;">【語彙】</span></span></span></span></div>
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<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'MS 明朝', serif;"><span style="color: red;"> </span><span style="color: red;">「<span style="color: black;">捏る</span>」はもともと「<span style="color: black;">こねる</span>」の意味。近頃は「<span style="color: black;">ツクる</span>」「<span style="color: black;">ネツる</span>」と訓読みするのがウケる。</span></span></span></span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"><span style="font-size: 14pt;">訪問者:「ちっ!開いた口が。。。」</span></span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;"> <span style="color: #ff0099;">さらに悪い冗談がその後のペーパーに・つ・づ・く。。。</span></span><span style="color: #009900;"> <span style="color: #ff0099; font-family: MS 明朝; font-size: xx-small;">♡</span> <a href="http://emoji7.jp/04uf5_715960/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84/" style="color: #b35400;"><sup><img alt="かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/04uf5_715960/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.gif" style="border: none;" /></sup></a></span></div>
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<span style="color: black; font-family: 'MS 明朝', serif; font-size: 14pt;">訪問者:「もう知らんぞ。どーなっても。<a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="You dummy! このバカちん!"><img alt="かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/050ad_708907/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.gif" style="border: none;" /></a>」</span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;"><a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="click here~♡"><img alt="" border="0" height="375" src="http://blog.m3.com/flyingmedicords/files/Circulation+2002+%28106%29%E3%82%A2%E3%83%B3%E3%82%B3%E3%82%A6%E3%81%AB%E3%81%A4%E3%81%A5%E3%81%91jpeg.jpg" style="border: none; height: 375px; width: 500px;" width="500" /></a> </span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;">―</span><span style="color: black; font-family: 'Calligraph421 BT'; font-size: 18pt;"> Wow! It sure is jaw-dropping. </span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 18pt;">―</span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> Delve a little bit further into the trick previously analyzed. When an image is cooked up into another image, the opposite is true. That is, image processing from 3-c to 2-c is possible, and vice-versa from 2-c to 3-c.</span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> If there were only two images, could you guess which is which? You can’t, I bet. Though you may say what is the point of delving it, but let’s see a faked image a little bit closer. It begins to seem like an O-sign mouth of an anglerfish, isn’t it? <a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="See? でしょん?"><img alt="実写、動物、かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/04ctj_717328/%E5%AE%9F%E5%86%99%E3%80%81%E5%8B%95%E7%89%A9%E3%80%81%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.GIF" style="border: none;" /></a></span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> Did you notice that each left edge of images (3-a, 3-b) without mouths were trimmed to look more real?</span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span><span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: small;"><span style="color: red;"> </span></span></span></div>
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<span style="color: black; font-family: 'Times New Roman', serif;"><span style="font-size: small;"><span style="color: red;"> <u>Supplementary Consideration</u><strong>:</strong> The original image 2-c was possibly cooked up to 3-c, and then for making mouths, each left edge of 3-b and 3-a was cut off in an artful way. Is that so?</span></span></span></div>
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<span style="font-size: small;"><span style="color: red;"><span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: red;"> <u>G</u></span><span style="color: red;"><u>lossary</u><strong>:</strong> Japanese word ‘</span></span><span style="color: black; font-family: 'MS 明朝', serif;">捏る</span></span><span style="color: red;"><span style="color: black; font-family: 'Times New Roman', serif;"><span style="color: red;">’</span><span style="color: red;">with an original meaning of ‘<span style="color: black;">Kone-ru</span>’ (v. <span style="color: black;">pug</span> in English) in kun reading, however, is more popularly pronounced ‘<span style="color: black;">Tuku-ru</span>’ or ‘<span style="color: black;">Netsu-ru</span>’ in these days.</span></span></span></span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;"><span style="color: black; font-size: 14pt;"> No shit! It sure is jaw-dropping.</span></span></span></div>
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"><span style="color: #ff0099;"> To be continued for more funny jokes in later papers.<span style="font-family: MS 明朝; font-size: xx-small;">♡</span><span style="color: #009900; font-family: Verdana; font-size: x-small;"> </span><a href="http://emoji7.jp/04uf5_715960/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84/" style="color: #b35400;"><sup><img alt="かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/04uf5_715960/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.gif" style="border: none;" /></sup></a></span></span></div>
<span style="color: #ff0099; font-family: MS Pゴシック; font-size: xx-small;"> </span><span style="font-family: MS Pゴシック; font-size: xx-small;"> </span><span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> </span><br />
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<span style="color: black; font-family: 'Times New Roman', serif; font-size: 14pt;"> I don’t care anymore what happens to you!<a href="http://english.blogmura.com/english_hyougen/" style="color: #b35400;" target="_blank" title="You dummy! このバカちん!"><img alt="かわいい のデコメ絵文字" border="0" src="http://gazo.emoji7.jp/img/050ad_708907/%E3%81%8B%E3%82%8F%E3%81%84%E3%81%84_m.gif" style="border: none;" /></a></span></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-7924118391970541372013-05-04T17:50:00.000+09:002013-05-17T07:50:22.029+09:00Cell. 2012 Jun 8;149(6):1298-313.<br />
<span role="menubar" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">Cell.</span><span style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;"> 2012 Jun 8;149(6):1298-313. doi: 10.1016/j.cell.2012.03.047.</span><br />
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
<span class="highlight">Complement</span> <span class="highlight">C1q</span> <span class="highlight">activates</span> <span class="highlight">canonical</span> <span class="highlight">Wnt</span> <span class="highlight">signaling</span> and <span class="highlight">promotes</span> <span class="highlight">aging-related</span> <span class="highlight">phenotypes</span>.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px;">Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A,Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.</span></span></div>
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Source</h3>
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Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/22682250">http://www.ncbi.nlm.nih.gov/pubmed/22682250</a></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529917/">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529917/</a></div>
<div style="margin-bottom: 0.5em; margin-top: 0.5em;">
<a href="http://www.cell.com/retrieve/pii/S0092867412005314">http://www.cell.com/retrieve/pii/S0092867412005314</a></div>
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<span style="font-family: Arial, Helvetica, sans-serif; font-size: large;">Download - <a href="http://kmb.prf.jcu.cz/userfiles/media/file/03_bryja.pdf">PDF file of the article (<span role="menubar" style="line-height: 19.625px;">Cell.</span><span style="line-height: 19.625px;"> 2012;149:1298-313) before erratum</span></a></span></div>
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Erratum in <a href="http://www.cell.com/retrieve/pii/S009286741200877X" style="font-size: 13.333333969116211px; line-height: 18.88888931274414px;">http://www.cell.com/retrieve/pii/S009286741200877X</a></h3>
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The article above reported a role for complement C1q in promoting age-related phenotypes. Since publication, we have noticed that the upper panels shown in<a class="ja50-ce-cross-ref" href="http://www.cell.com/retrieve/pii/S009286741200877X#fig7" name="back-fig7" style="color: #005587; text-decoration: none;">Figure 7</a>F were incorrectly selected and labeled. The upper-right panel portrayed an image from aged C1qKO mice, not aged wild-type mice treated with M241, as originally labeled. The upper-left panel was correctly labeled as aged wild-type mice treated with PBS, but the magnification of both images in the top panels was incorrectly labeled and did not match the magnification of the bottom two panels. The corrected figure, with the upper-left panel now portraying an image from aged wild-type mice treated with PBS and the upper-right panel portraying an image from aged wild-type mice treated with M241, both taken with a 4× magnification (scale bars, 150 μm), is shown on the following page. We sincerely apologize for these mistakes and emphasize that the correction of these errors does not impact our conclusions</div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-62974210591630937382013-05-04T17:49:00.000+09:002013-06-10T23:17:52.876+09:00Nature. 2012 May 10;485(7397):251-5.<br />
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<span role="menubar">Nature.</span> 2012 May 10;485(7397):251-5. doi: 10.1038/nature10992.</div>
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<span class="highlight">Mitochondrial</span> <span class="highlight">DNA</span> that <span class="highlight">escapes</span> from <span class="highlight">autophagy</span> <span class="highlight">causes</span> <span class="highlight">inflammation</span>and <span class="highlight">heart</span> <span class="highlight">failure</span>.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.666666984558105px;">Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda<b> </b>T, Tamai T, Oyabu J, Murakawa T, Nakayama H,Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K.</span></span></div>
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Source</h3>
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Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/22535248">http://www.ncbi.nlm.nih.gov/pubmed/22535248</a></div>
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<a href="http://basicmed.med.ncku.edu.tw/public/project/1225-1348566873-1.pdf">http://basicmed.med.ncku.edu.tw/public/project/1225-1348566873-1.pdf</a></div>
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<a href="http://www.nature.com/nature/journal/v485/n7397/full/nature10992.html">http://www.nature.com/nature/journal/v485/n7397/full/nature10992.html</a></div>
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<span style="color: red; font-size: large;"><b><span style="font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; line-height: 23.90625px;">In Fig. 4d, the panel showing CD3 staining for ODN2088 control-treated TAC-operated </span><i style="font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; line-height: 23.90625px;">Dnase2a</i><sup style="font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; line-height: 0; margin-left: 0.15em;">+/+</sup><span style="font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; line-height: 23.90625px;"> mice i</span><span style="font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; line-height: 23.90625px;">s a duplicate of that showing Ly6G staining for ODN2088-treated TAC-operated </span><i style="font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; line-height: 23.90625px;">Dnase2a</i><sup style="font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; line-height: 0; margin-left: 0.15em;">−/−</sup><span style="font-family: arial, helvetica, 'MS Pゴシック', 'MS ゴシック', Osaka, 'MS PGothic', sans-serif; line-height: 23.90625px;"> mice. </span></b></span></div>
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<a href="https://twitter.com/JuuichiJigen/status/218894228762279936">https://twitter.com/JuuichiJigen/status/218894228762279936</a></div>
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大阪大学大学院医学系研究科 循環器内科学 Nature誌論文 Fig.4d 最下段(CD3)の一番左の画像が、上から3段目(Ly6G)の一番右の画像と同一。 <a class="twitter-timeline-link" data-expanded-url="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10992.html" dir="ltr" href="http://t.co/up0hEfTj" rel="nofollow" style="color: #0084b4; text-decoration: none;" target="_blank" title="http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10992.html"><span class="invisible" style="font-size: 0px; line-height: 0;">http://www.</span><span class="js-display-url">nature.com/nature/journal</span><span class="invisible" style="font-size: 0px; line-height: 0;">/vaop/ncurrent/full/nature10992.html</span><span class="tco-ellipsis"><span class="invisible" style="font-size: 0px; line-height: 0;"> </span>…</span></a> ケアレスミスか?念のため、他にも調査の必要性があるか?</div>
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(その後、Corrigendum が出される。指摘の件以外にも、多数の不適切な画像操作が判明)</div>
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Erratum in</h3>
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<span style="font-family: arial, helvetica, clean, sans-serif; font-size: x-small;"><span style="line-height: 15.4375px;">Nature. 2012 Oct 11;490(7419):292.</span></span></div>
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<a href="http://dx.doi.org/10.1038/nature10992" style="color: #5c7996; text-decoration: none;"><i>Nature</i> <b>485</b>, <span class="start-page">251</span>–<span class="end-page">255</span> (<span class="year">2012</span>); doi:10.1038/nature10992</a></div>
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In this Letter, several images were mistakenly switched or duplicated during preparation of the artwork. In Figs 1f and 2a, the sham-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">−/−</sup> and TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup> mice panels were switched. In Fig. 4d, the panel showing CD3 staining for ODN2088 control-treated TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup> mice (now shown correctly as black-bordered panel in <a href="http://www.nature.com/nature/journal/v490/n7419/full/nature11515.html#f1" style="color: #5c7996; text-decoration: none;">Fig. 1</a> below) is a duplicate of that showing Ly6G staining for ODN2088-treated TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">−/−</sup> mice. The panel showing CD45 staining for ODN2088-treated TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup> (now shown correctly as blue-bordered panel in <a href="http://www.nature.com/nature/journal/v490/n7419/full/nature11515.html#f1" style="color: #5c7996; text-decoration: none;">Fig. 1</a> below) was prepared from the original picture of ODN2088 control-treated TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup>. In Supplementary Fig. 4c, sham-operated<i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">−/−</sup> and TAC-operated <i>Dnase2a</i><sup style="font-size: 12.222222328186035px; line-height: 0; margin-left: 0.15em;">+/+</sup> mice panels were switched. Finally, in Supplementary Fig. 10d, the panels showing CD3 and Ly6G staining for sham-operated <i>Tlr9<sup style="font-size: 12.222222328186035px; line-height: 0;">+/+</sup></i> mice were switched. These corrections do not alter any of the conclusions of this Letter, and the authors apologize for any confusion these errors may have caused.</div>
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<a href="http://blog.goo.ne.jp/lemon-stoism/e/e0f3e1732313be85a6acc20151bf11ac" style="color: #00a9d9; text-decoration: none;">大阪大学医学系グループが不適切研究!</a> (<span style="line-height: 1.1;">ブログ </span><span style="line-height: 1.1;">世界変動展望)</span></h3>
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<a href="http://blog.goo.ne.jp/lemon-stoism/e/e0f3e1732313be85a6acc20151bf11ac">http://blog.goo.ne.jp/lemon-stoism/e/e0f3e1732313be85a6acc20151bf11ac</a></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-17521424820037253992013-05-04T17:48:00.000+09:002013-06-10T23:15:49.998+09:00J Atheroscler Thromb. 2012;19(3):263-75.<br />
<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<span role="menubar">J Atheroscler Thromb.</span> 2012;19(3):263-75. Epub 2011 Nov 10.</div>
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Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases.</h1>
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<span style="color: #660066; font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.44444465637207px;">Yuasa-Kawase M, Masuda D, Yamashita T, Kawase R, Nakaoka H, Inagaki M, Nakatani K, Tsubakio-Yamamoto K,Ohama T, Matsuyama A, Nishida M, Ishigami M, Kawamoto T, Komuro I, Yamashita S.</span></span></div>
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Source</h3>
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Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/22075538">http://www.ncbi.nlm.nih.gov/pubmed/22075538</a></div>
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<a href="https://www.jstage.jst.go.jp/article/jat/19/3/19_10603/_article">https://www.jstage.jst.go.jp/article/jat/19/3/19_10603/_article</a></div>
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<span style="color: red; font-size: large;"><b>Fig.2 (A is the same as C)</b></span></div>
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<a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiFx9TAh7hTvmOIXLS6DKMZUyeQlhc6aj5EsNS9t6dwqFGoqqSbHj1Lbl1LQBKGJOdbvs1mnaDkExXPrJ29_YwEJZ8cgfDzsrH4hhv5eNlEZ9cLNFl8o84xY54ubyEkDh4BTmfKl3SUkiW7/s1600/Fig2+copy.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="287" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiFx9TAh7hTvmOIXLS6DKMZUyeQlhc6aj5EsNS9t6dwqFGoqqSbHj1Lbl1LQBKGJOdbvs1mnaDkExXPrJ29_YwEJZ8cgfDzsrH4hhv5eNlEZ9cLNFl8o84xY54ubyEkDh4BTmfKl3SUkiW7/s400/Fig2+copy.jpg" width="400" /></a></div>
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今話題の阪大循環器内科グループの論文:J Atheroscler Thromb. 2012;19(3):263-75. Fig.2A (RCA) と Fig.2C (RCIA) の写真が同一。<a class="twitter-timeline-link" data-expanded-url="https://www.jstage.jst.go.jp/article/jat/19/3/19_10603/_pdf" dir="ltr" href="https://t.co/fQvw0kIWar" rel="nofollow" style="color: #0084b4; text-decoration: none;" target="_blank" title="https://www.jstage.jst.go.jp/article/jat/19/3/19_10603/_pdf"><span class="invisible" style="color: #0084b4; font-size: 0px; line-height: 0; text-decoration: none;">https://www.</span><span class="js-display-url" style="color: #0084b4; text-decoration: none;">jstage.jst.go.jp/article/jat/19</span><span class="invisible" style="color: #0084b4; font-size: 0px; line-height: 0; text-decoration: none;">/3/19_10603/_pdf</span><span class="tco-ellipsis" style="color: #0084b4; text-decoration: none;"><span class="invisible" style="font-size: 0px; line-height: 0;"> </span>…</span></a></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-87011314663892481482013-05-04T17:46:00.000+09:002014-02-20T21:50:41.251+09:00Nat Med. 2009 Sep;15(9):1082-7.<br />
<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<span role="menubar">Nat Med.</span> 2009 Sep;15(9):1082-7. doi: 10.1038/nm.2014. Epub 2009 Aug 30.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
A crucial role for adipose tissue p53 in the regulation of insulin resistance.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.666666984558105px;">Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F,Komuro I.</span></span></div>
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Source</h3>
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Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/19718037">http://www.ncbi.nlm.nih.gov/pubmed/19718037</a></div>
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<a href="http://www.nature.com/nm/journal/v15/n9/full/nm.2014.html">http://www.nature.com/nm/journal/v15/n9/full/nm.2014.html</a></div>
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<a href="http://www.nature.com/nm/journal/v15/n9/pdf/nm.2014.pdf">http://www.nature.com/nm/journal/v15/n9/pdf/nm.2014.pdf</a></div>
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<b style="background-color: #f3f3f3;"><span style="color: #292f33; font-family: Helvetica Neue, Arial, Hiragino Kaku Gothic Pro, Meiryo, MS PGothic, sans-serif;"><span style="font-size: 15px; line-height: 18px; white-space: pre-wrap;">Surprisingly</span></span><span style="color: #292f33; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 15px; line-height: 18px; white-space: pre-wrap;">, In Jan, 2014, </span><span style="color: #292f33; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.666666984558105px; line-height: 18px; white-space: pre-wrap;">Nature Publishing Group replaced the following misused image data in </span><span style="color: #292f33; font-family: Helvetica Neue, Arial, Hiragino Kaku Gothic Pro, Meiryo, MS PGothic, sans-serif;"><span style="font-size: 15px; line-height: 18px; white-space: pre-wrap;">Supplemental Fig. 2c </span></span><span style="color: #292f33; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.666666984558105px; line-height: 18px; white-space: pre-wrap;">with new one without any notice in the Nature Medicine article (</span><span style="color: #292f33; font-family: Helvetica Neue, Arial, Hiragino Kaku Gothic Pro, Meiryo, MS PGothic, sans-serif;"><span style="font-size: 15px; line-height: 18px; white-space: pre-wrap;">2009 Sep;15(9):)</span></span><span style="color: #292f33; font-family: 'Helvetica Neue', Arial, 'Hiragino Kaku Gothic Pro', Meiryo, 'MS PGothic', sans-serif; font-size: 14.666666984558105px; line-height: 18px; white-space: pre-wrap;">! </span></b></div>
<span style="color: #292f33; font-family: Helvetica Neue, Arial, Hiragino Kaku Gothic Pro, Meiryo, MS PGothic, sans-serif;"><span style="font-size: 15px; line-height: 18px; white-space: pre-wrap;"><b style="background-color: #f3f3f3;">Please compare the following old images and new images.</b></span></span><br />
<span style="color: #292f33; font-family: Helvetica Neue, Arial, Hiragino Kaku Gothic Pro, Meiryo, MS PGothic, sans-serif;"><b style="background-color: #f3f3f3;"><span style="font-size: 15px; line-height: 18px; white-space: pre-wrap;"> (New image: </span><span style="font-size: 15px; line-height: 18px; white-space: pre-wrap;"><a href="http://www.nature.com/nm/journal/v15/n9/suppinfo/nm.2014_S1.html">http://www.nature.com/nm/journal/v15/n9/suppinfo/nm.2014_S1.html</a>).</span></b></span></div>
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<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><span style="line-height: 18.18181800842285px;"><b>"WT (HF/HS)" and "G4 (HF/HS)" in Supplemental Fig. 2c and "Pre operation" in Supplemental Fig. 2d are similar CT scan images. These images may be derived from the identical patient.</b></span></span></div>
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<span style="background: #EFEFEF;">Supplemental Fig. 2c</span></span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">の一番右、</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Lean tissue/BW</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">の棒グラフの</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">G4 (HS/HS)</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">と</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">G4 Trp53+/- (HS/HS)</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">は、</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">mean</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">と</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">SEM</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">が完全に一致。遺伝型が違うのに</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">n=5</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">で</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">mean</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">と</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">SEM</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">が完全一致するのは極めて稀</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">?CT scan</span><span lang="JA" style="background-color: #efefef; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">のこれだけ似た画像を元に作ればあり得る</span><span style="background-color: #efefef; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">?<span class="apple-converted-space"> </span></span></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-30027145828482763222013-05-04T17:45:00.000+09:002013-06-11T01:56:18.999+09:00Nature. 2008 Jul 17;454(7202):345-9.<br />
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<span role="menubar">Nature.</span> 2008 Jul 17;454(7202):345-9. doi: 10.1038/nature07027. Epub 2008 Jun 4.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15px;">Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T,Kikuchi A, Asashima M, Komuro I.</span></span></div>
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Source</h3>
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Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/18528331">http://www.ncbi.nlm.nih.gov/pubmed/18528331</a></div>
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<a href="http://www.nature.com/nature/journal/v454/n7202/full/nature07027.html">http://www.nature.com/nature/journal/v454/n7202/full/nature07027.html</a></div>
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<a href="http://www.nature.com/nature/journal/v454/n7202/pdf/nature07027.pdf">http://www.nature.com/nature/journal/v454/n7202/pdf/nature07027.pdf</a></div>
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<span style="font-family: Arial, Helvetica, sans-serif; font-size: large;"><span style="line-height: 17.45833396911621px;"><b>Concern#1</b></span></span><br />
<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><span style="line-height: 17.45833396911621px;"><b>In the beta-actin panel of Fig.1C, a left band (OP-9) is similar to a right band (OP-9 + anti-BP4).</b></span></span><br />
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<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large; line-height: 17.45833396911621px;"><b>In the beta-Actin panel of Fig.3B, lane 1 and lane 2 bands from the left are similar.</b></span><br />
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<b style="font-family: Arial, Helvetica, sans-serif; font-size: x-large; line-height: 17.45833396911621px;">Concern#3</b></div>
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<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large; font-weight: bold; line-height: 1.0915em;">In Fig.3e, lane 3 and 5 bands from the left of a "alpha-MHC" panel are inappropriately erased, and Lane 1, 4 and 6 of the "alpha-MHC" panel and lane 5 of a "GATA-4" panel are similar to each other.</span></div>
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<span style="line-height: 17.45833396911621px;"><b style="background-color: white; font-family: Arial, Helvetica, sans-serif; font-size: x-large;">Concern#4</b></span><br />
<span style="line-height: 17.45833396911621px;"><b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">In the "GATA-4" panel of Fig.3e, lane 1 and lane 6 bands from the left are similar to each other"</span></b></span><br />
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<span style="line-height: 17.45833396911621px;"><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><b>In Fig.3e, Lane 1 and 2 image from the left of a GATA-4 panel are a vertically flipped and resized version of lane 1 and 2 image from the left of Nkx2.5 panel.</b></span></span><br />
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<b style="font-family: Arial, Helvetica, sans-serif; font-size: x-large; line-height: 17.45833396911621px;">Concern#6</b></div>
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<span style="color: red; font-family: arial, helvetica, clean, sans-serif; font-size: large;"><span style="line-height: 14.770833015441895px;"><b>In Supplementary Figure S3e, the left band of "Nkx2.5 (-)" panel is the same as the right band of "GATA4 BP4-2" panel.</b></span></span></div>
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<b style="font-family: Arial, Helvetica, sans-serif; font-size: x-large; line-height: 17.45833396911621px;">Concern#7</b><br />
<span style="color: red; font-family: arial, helvetica, clean, sans-serif; font-size: large;"><span style="line-height: 17.45833396911621px;"><b>In Supplementary Figure S3f, the left band of beta-actin panel is a resized version of that of Nkx2.5 panel.</b></span></span></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-77395360924655029282013-05-04T17:42:00.000+09:002013-06-10T23:18:22.397+09:00<br />
<div class="cit" style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 0.8465em; line-height: 1.45em;">
<span role="menubar">J Biol Chem.</span> 2004 Mar 19;279(12):11384-91. Epub 2003 Dec 31.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.666666984558105px;">Matsuura K, Nagai T, Nishigaki N, Oyama T, Nishi J, Wada H, Sano M, Toko H, Akazawa H, Sato T, Nakaya H, Kasanuki H,Komuro I.</span></span></div>
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Source</h3>
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Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/14702342">http://www.ncbi.nlm.nih.gov/pubmed/14702342</a></div>
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<a href="http://www.jbc.org/content/279/12/11384.long">http://www.jbc.org/content/279/12/11384.long</a></div>
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<span style="background-color: #efefef; line-height: 115%;"><b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">In Fig3, a "MLC-2V" image is the same as a "cardiac alpha-actin" image.</span></b></span></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-6365754872819833562013-05-04T17:41:00.000+09:002013-06-11T08:16:02.985+09:00Biochem Biophys Res Commun. 2004 Sep 10;322(1):310-9.<br />
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<span role="menubar">Biochem Biophys Res Commun.</span> 2004 Sep 10;322(1):310-9.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Atrial natriuretic peptide inhibits cardiomyocyte hypertrophy through mitogen-activated protein kinase phosphatase-1.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.44444465637207px;">Hayashi D, Kudoh S, Shiojima I, Zou Y, Harada K, Shimoyama M, Imai Y, Monzen K, Yamazaki T, Yazaki Y,Nagai R, Komuro I.</span></span></div>
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Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/15313208">http://www.ncbi.nlm.nih.gov/pubmed/15313208</a><br />
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<b><span style="color: red; font-size: large;">In Fig.2A, a "ANP" band image of c-fos blot is similar to the horizontally flipped image of "8-Bromo-cGMP" band image of c-fos blot.</span></b><br />
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<span style="color: red; font-size: large; line-height: 1.0915em;"><b>In Fig.2A, a "ANP" band image of 18S panel is similar to the horizontally flipped image of "8-Bromo-cGMP" band image of 18S panel.</b></span><br />
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<span style="background-color: #f3f3f3; color: red; font-family: Calibri, sans-serif; font-size: large; line-height: 115%;"><b>In a 28S panes of Fig.2B, lane 1, 2, and 3 band images are identical to lane 4, 5, and 6 band images, respectively.</b></span><br />
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<span style="background-color: #f3f3f3; font-family: Calibri, sans-serif; line-height: 115%;">Fig. 2B<span class="apple-converted-space"> </span></span></b></span><span style="font-family: Calibri, sans-serif; line-height: 115%;"><span style="color: red; font-size: large;"><b><span style="background-color: #f3f3f3;"><br />
28S Lane 1 = 28S Lane 4<br />
28S Lane 2 = 28S Lane 5<span class="apple-converted-space"> </span><br />
28S Lane 3 = 28S Lane 6<span class="apple-converted-space"> </span></span></b></span>
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<b><span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #efefef; color: red; font-size: large; line-height: 115%;">In Fig.5A, Lane 3, 4, 5, and 6 band images from the left of top 28S panel are identical to lane 1, 2, 3, and 4 band images from the left of bottom 28S panel.</span></span></b><br />
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-74393430320522029202013-05-04T17:40:00.000+09:002013-06-11T03:32:11.949+09:00Nat Cell Biol. 2004 Jun;6(6):499-506. <br />
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<span role="menubar">Nat Cell Biol.</span> 2004 Jun;6(6):499-506. Epub 2004 May 16.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.</h1>
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Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H,Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I.</div>
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Source</h3>
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Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/15146194">http://www.ncbi.nlm.nih.gov/pubmed/15146194</a></div>
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<a href="http://www.nature.com/ncb/journal/v6/n6/full/ncb1137.html">http://www.nature.com/ncb/journal/v6/n6/full/ncb1137.html</a></div>
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<span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;"><b>The lane 3 band of top panel in Fig.2e is the same image as the 2nd image from the left of Fig.3e.</b></span><br />
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<b><span style="color: red; font-family: Arial, Helvetica, sans-serif; font-size: large;">The rightmost band of the bottom panel in Fig.2f is identical to the rightmost band in Fig.2h.</span></b><br />
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-51638268228237560122013-05-04T17:35:00.000+09:002013-05-06T03:51:46.205+09:00Circulation. 2003 Dec 16;108(24):3024-30<br />
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<span role="menubar">Circulation.</span> 2003 Dec 16;108(24):3024-30. Epub 2003 Nov 17.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 14.666666984558105px;">Zou Y, Zhu W, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A, Komuro I.</span></span></div>
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Source</h3>
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Department of Cardiovascular Science and Medicine, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. komuro-tky@umin.ac.jp</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/14623809">http://www.ncbi.nlm.nih.gov/pubmed/14623809</a></div>
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<a href="http://circ.ahajournals.org/content/108/24/3024.long">http://circ.ahajournals.org/content/108/24/3024.long</a></div>
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<span style="font-family: Arial, Helvetica, sans-serif; font-size: large;"><b style="background-color: #f3f3f3;"><span style="background: #EFEFEF; color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">Fig. 5c Sham TG</span><span lang="JA" style="background: #EFEFEF; color: black; font-family: "MS Mincho"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin;">と</span><span style="background: #EFEFEF; color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;">I/R TG</span><span lang="JA" style="background: #EFEFEF; color: black; font-family: "MS Mincho"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-font-family: Calibri; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-font-family: Calibri; mso-hansi-theme-font: minor-latin;">の上部のバンドが類似?</span><span class="apple-converted-space"><span style="background: #EFEFEF; color: black; font-family: "Calibri","sans-serif"; font-size: 13.5pt; line-height: 115%; mso-ansi-language: EN-US; mso-ascii-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-language: AR-SA; mso-bidi-theme-font: minor-bidi; mso-fareast-font-family: "MS Mincho"; mso-fareast-language: JA; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-latin;"> </span></span></b></span></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-57211119318968115702013-05-04T17:30:00.000+09:002013-05-10T04:46:33.839+09:00Circulation. 2002 Mar 12;105(10):1240-6.<br />
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<span role="menubar"><span class="highlight">Circulation</span>.</span> <span class="highlight">2002</span> Mar 12;<span class="highlight">105</span>(<span class="highlight">10</span>):<span class="highlight">1240-6</span>.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px;">Asakawa M, Takano H, Nagai T, Uozumi H, Hasegawa H, Kubota N, Saito T, Masuda Y, Kadowaki T, Komuro I.</span></span></div>
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Source</h3>
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Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/11889020">http://www.ncbi.nlm.nih.gov/pubmed/11889020</a></div>
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<a href="http://circ.ahajournals.org/content/105/10/1240.long">http://circ.ahajournals.org/content/105/10/1240.long</a></div>
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高解像度のHTML版(有料契約経路)から画像をダウンロードして比較してください(無料版は画像がダウンロードできなくなっているようです)。</div>
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PDF版は低解像度ですので類似性を比較するのは難しいです。<br />
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<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #eeeeee; line-height: 14.541666984558105px;"><b>Fig1A</b></span></span><b style="background-color: white; font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 14.541666984558105px;"> Skeletal alpha-actin 右から1-3列とFig1B Skeletal alpha-actin 右から2-4列が類似?</b></div>
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<span style="background-color: #eeeeee; line-height: 14.53125px;"><b><span style="font-family: Arial, Helvetica, sans-serif;">Fig1 A</span></b></span><b style="background-color: white; font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="line-height: 14.53125px;"><span style="font-family: Arial, Helvetica, sans-serif;"> ANPの左から2-4レーンとFig1 B ANP 左から5-7レーンが類似?</span></b></div>
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<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #eeeeee; line-height: 14.53125px;"><b>Fig1 A</b></span></span><b style="background-color: white; font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 14.53125px;"> 18S 1-4レーンとFog1B 18S 左1-4が類似?</b></div>
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<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #eeeeee; line-height: 14.53125px;"><b>Fig1A</b></span></span><b style="font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 14.53125px;"> 18S 左から1レーン目と2レーン目が類似?</b><br />
<span style="font-family: Arial, Helvetica, sans-serif;"><span style="background-color: #eeeeee; line-height: 14.53125px;"><b>Fig1A</b></span></span><b style="font-family: Arial, Helvetica, sans-serif; line-height: 17.77777862548828px;">、</b><b style="font-family: Arial, Helvetica, sans-serif; line-height: 14.53125px;"> 18S 左から3レーン目と4レーン目が類似?</b></div>
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0tag:blogger.com,1999:blog-9012689239955772419.post-5760850028339846792013-05-04T17:15:00.000+09:002013-06-10T23:14:22.179+09:00J Biol Chem. 1999 Mar 19;274(12):8231-9.<br />
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<span role="menubar">J Biol Chem.</span> 1999 Mar 19;274(12):8231-9.</div>
<h1 style="background-color: white; font-family: arial, helvetica, clean, sans-serif; font-size: 1.231em; line-height: 1.125em; margin: 0.375em 0px;">
Context-dependent transcriptional cooperation mediated by <span class="highlight">cardiac</span> transcription factors Csx/Nkx-2.5 and GATA-4.</h1>
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<span style="font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px;">Shiojima I, Komuro I, Oka T, Hiroi Y, Mizuno T, Takimoto E, Monzen K, Aikawa R, Akazawa H, Yamazaki T, Kudoh S, Yazaki Y.</span></span></div>
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Source</h3>
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Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.</div>
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<a href="http://www.ncbi.nlm.nih.gov/pubmed/10075728">http://www.ncbi.nlm.nih.gov/pubmed/10075728</a></div>
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<a href="http://www.jbc.org/content/274/12/8231.long">http://www.jbc.org/content/274/12/8231.long</a></div>
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<span style="color: red; font-size: large;">A "TTF1" image in Fig.2B is identical to a "NKE2" image in Fig.2C.</span></div>
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<span style="background-color: white; font-family: arial, helvetica, clean, sans-serif;"><span style="font-size: 15.0150146484375px; line-height: 16.375749588012695px;"><br /></span></span>
<span style="background-color: #eeeeee;"><span style="font-family: Arial, Helvetica, sans-serif;"><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">なお、</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">Fig. 7</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">の左側の</span><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;">CSX+ GATA-4+</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">のレーンにも上部右にドット状のノイズがあり、</span><span class="apple-converted-space" style="line-height: 1.0915em;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span><span style="line-height: 115%;"><br />
</span><span lang="JA" style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: 'MS Mincho'; font-size: 13.5pt; line-height: 115%;">左のレーンとつなぎ合わせた痕跡を下部や中央部に感じる</span><span class="apple-converted-space" style="line-height: 1.0915em;"><span style="background-color: #efefef; background-position: initial initial; background-repeat: initial initial; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"> </span></span></span></span><span style="background-color: white; font-family: Calibri, sans-serif; font-size: 13.5pt; line-height: 115%;"><br />
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11jigenhttp://www.blogger.com/profile/03513633746083109180noreply@blogger.com0